Jalel Kadri watched his side claim a 2-0 victory over Iran in last week's final warm-up friendly against Iran, with late second-half goals coming from Naim Sliti and Cean man Ali Abdi.
However, Sliti appears likely to drop out of the midfield, with the more experienced Aissa Laidouni and FC Koln's Ellyes Skhiri, who has 49 international caps, coming into the fold.
Manchester United teenager Hannibal Mejbri, who is currently on loan at Birmingham City, has already racked up 19 appearances for the Carthage Eagles and the 19-year-old is in line to make his first World Cup appearance.
Off the back of keeping an eighth clean sheet in nine matches, we expect to see a back four of Abdi, Dylan Bronn, Montassar Talbi, and 26-year-old Mohamed Drager, shielding goalkeeper Aymen Dahmen.
At the opposite end of the pitch, Wahbi Khazri and Youssef Msakni have netted a combined 41 goals for Tunisia and the veteran duo will spearhead the attack on Tuesday.
With Brondby's Ben Slimane expected to feature out wide on the left, Taha Yassine Khenissi and Zamalek forward Seifeddine Jaziri, who has scored 10 goals since his debut in January 2016.
Tunisia possible starting lineup: Dahmen; Drager, Talbi, Bronn, Abdi; Skhiri, Chaaleli, Laidouni; Slimane, Msakni, Khazri