The Lilywhites are back from a weather-affected trip to Thailand and Singapore - thrashing the Lion City Sailors 5-1 last time out - but they have since lost Bryan Gil to groin surgery.
Gil joins Ryan Sessegnon (hamstring) and Rodrigo Bentancur (ACL) on the list of players recovering from operations, although Yves Bissouma should be good to go despite a brief ankle scare.
However, Tottenham will take on Barcelona in the Joan Gamper Trophy only two days after Sunday's showdown, so Postecoglou should no doubt limit some of his more celebrated names to shorter run-outs ahead of the trip to Catalonia.
Brandon Austin could therefore be given the nod in goal, although Cristian Romero and Ben Davies could still comprise an experienced central pairing, as Spurs try to get deals for the youthful Ashley Phillips and Micky van de Ven over the line.
Sergio Reguilon and Emerson Royal ought to line up in the wide areas, and with Postecoglou surely seeing no need to risk Bissouma, Oliver Skipp could link arms with Pape Sarr and Giovani Lo Celso in the middle.
Youngsters such as Alfie Devine and Harvey White should also earn some valuable first-team minutes here, while Manor Solomon will be expected to start against the club he controversially left on a free transfer this summer.
With Solomon charging down the right flank, Ivan Perisic ought to line up on the left in support of Richarlison, who netted a hat-trick in the Lilywhites' thumping of the Lion City Sailors.
Tottenham Hotspur possible starting lineup: Austin; Emerson, Romero, Davies, Reguilon; Sarr, Skipp, Lo Celso; Solomon, Richarlison, Perisic