After rotating his resources at the weekend, the Spanish club's coach Jose Luis Mendilibar will naturally revert to his strongest XI at the Puskas Arena, so Manu Bueno and Rafa Mir - who scored against Real Madrid on Saturday - should be two of those demoted to the bench.
Following precedent in this term's competition, Morocco international Yassine Bounou replaces first-choice Marko Dmitrovic in goal, behind Los Rojiblancos' probable 4-2-3-1 formation.
Joining Suso and Joan Jordan in recovering from recent injuries to make the trip, defensive duo Marcao and Tanguy Nianzou could be back among the Sevilla substitutes; leaving Mendilibar with a virtually full squad to choose from.
Also sent off at the weekend, Marcos Acuna is suspended for the final, though, which should see Alex Telles featuring at left-back.
Veteran right-back Jesus Navas - who won the UEFA Cup with the club 17 years ago - will captain the side, with Loic Bade and Nemanja Gudelj set to be partnered in central defence.
Youssef En-Nesyri has scored three goals across the last two rounds, so should replace Mir up front. Lucas Ocampos and Oliver Torres could also return, starting in support of the in-form striker.
Sevilla possible starting lineup: Bounou; Navas, Bade, Gudelj, Telles; Fernando, Rakitic; Ocampos, Torres, Gil; En-Nesyri
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