Julen Lopetegui's side, who are currently fourth in the table, six points behind leaders Atletico Madrid, are expected to have a fully-fit squad for the clash with Los Blancos.
Indeed, Joan Jordan should overcome a toe problem to feature in the middle of the park, while both Youssef En-Nesyri and Jules Kounde are likely to be available despite missing training sessions this week.
The majority of the Sevilla team picks itself, with Jesus Navas and Marcos Acuna operating in the full-back positions and Kounde joining Diego Carlos in the middle of the defence.
Lucas Ocampos and Suso, meanwhile, should feature either side of En-Nesyri, who is the team's leading scorer this season, having found the back of the net on 23 occasions in all competitions.
The only major talking point comes in the middle of the park, where Jordan faces competition from Papu Gomez to start alongside Ivan Rakitic and Fernando.
Jordan should just about get the nod if he can prove his fitness, though, with Gomez set to start on the bench alongside the likes of Luuk de Jong, Oliver Torres and Oscar Rodriguez.
Sevilla possible starting lineup: Bounou; Navas, Kounde, Carlos, Acuna; Rakitic, Fernando, Jordan; Suso, En-Nesyri, Ocampos
> Click here to see how Real Madrid could line up for this contest