Former coach Fonseca was forced to withdraw both Jordan Veretout and Leonardo Spinazzola last Thursday, with the pair since having missed out on Sunday's defeat to Sampdoria. Meanwhile, Amadou Diawara and former Barcelona academy graduate Carles Perez were also sidelined at the weekend, so Gonzalo Villar and Henrikh Mkhitaryan are favoured to start.
Despite re-joining training, injury-plagued rising star Nicolo Zaniolo is yet to recover full fitness after tearing his ACL last autumn, with his comeback now expected to be pushed back until next season. Wing-back Bruno Peres should, though, overcome a knock sustained last time out - however experienced forwards Stephan El Shaarawy and Pedro are still nursing thigh strains.
In further bad news for the Serie A side, first-choice goalkeeper Pau Lopez will miss the remainder of the season, as he requires shoulder surgery after being forced off in the first leg and - though third-choice Daniel Fuzato was given a rare opportunity at the weekend - veteran stopper Antonio Mirante is expected to deputise on Thursday.
Roma possible starting lineup: Mirante; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Villar, Peres; Pellegrini, Mkhitaryan; Dzeko
> Click here to see how Manchester United could line up for this contest
Real Madrid 
Sevilla 
Cremonese 
Sampdoria 
Tottenham 
Liverpool 
VFL Wolfsburg 
Borussia Dortmund 
Las Palmas 
Espanyol 
Monza 
Juventus 
Lens 
Paris Saint Germain 
Fiorentina 
Udinese 
Benfica 
Estoril 
Inter 
Como 
Manchester City 
Everton 
Chelsea 
Fulham 
Nottingham Forest 
Celtic 
Motherwell 
Wolverhampton 
Manchester Utd 
ST Mirren 
Rangers 
Carrarese 
Leicester 
Arsenal 
Ipswich 
Cagliari 
Lazio 
Atalanta 
FC Porto 
Boavista 
Torino 
Napoli 
Venezia 
ST Johnstone