Former coach Fonseca was forced to withdraw both Jordan Veretout and Leonardo Spinazzola last Thursday, with the pair since having missed out on Sunday's defeat to Sampdoria. Meanwhile, Amadou Diawara and former Barcelona academy graduate Carles Perez were also sidelined at the weekend, so Gonzalo Villar and Henrikh Mkhitaryan are favoured to start.
Despite re-joining training, injury-plagued rising star Nicolo Zaniolo is yet to recover full fitness after tearing his ACL last autumn, with his comeback now expected to be pushed back until next season. Wing-back Bruno Peres should, though, overcome a knock sustained last time out - however experienced forwards Stephan El Shaarawy and Pedro are still nursing thigh strains.
In further bad news for the Serie A side, first-choice goalkeeper Pau Lopez will miss the remainder of the season, as he requires shoulder surgery after being forced off in the first leg and - though third-choice Daniel Fuzato was given a rare opportunity at the weekend - veteran stopper Antonio Mirante is expected to deputise on Thursday.
Roma possible starting lineup: Mirante; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Villar, Peres; Pellegrini, Mkhitaryan; Dzeko
> Click here to see how Manchester United could line up for this contest
Monaco 
Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
Paris Saint Germain 
Toulouse 
CSKA Moscow 
FC Rostov 
Leicester 
Chelsea 
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
Lokomotiv Moscow 
Rangers 
Dundee Utd 
Atletico Madrid 
Alaves 
Lens 
Marseille 
Ingulets Petrove 
Shakhtar Donetsk 
AC Milan 
Juventus 
ST Malo 
Manchester City 
Tottenham 
Eintracht Frankfurt 
Werder Bremen 
Girona 
Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen