Los Blancos, who are currently second in the La Liga table, two points behind leaders Atletico Madrid, will definitely be without the services of Lucas Vazquez, Dani Carvajal and Raphael Varane this weekend through injury.
Sergio Ramos, Federico Valverde and Vinicius Junior all missed group training on Friday, meanwhile, meaning that the trio have emerged as major doubts for the contest in the Spanish capital.
Head coach Zinedine Zidane could be forced to switch to a back three, with Alvaro Odriozola and fit-again Ferland Mendy featuring in the full-back positions.
Zidane cannot afford to make wholesale changes from the side that lost 2-0 to Chelsea in the second leg of their Champions League semi-final on Wednesday evening due to the importance of this match.
As a result, Toni Kroos, Casemiro, Luka Modric and Karim Benzema will all start, while there could be a spot in the final third of the field for Marco Asensio, particularly if Vinicius is unavailable.
Eden Hazard's performance against Chelsea and conduct after the match has been heavily criticised, but the Belgium international might be handed another opportunity to prove himself here.
Real Madrid possible starting lineup: Courtois; Odriozola, Militao, Nacho, Mendy; Modric, Casemiro, Kroos; Hazard, Benzema, Asensio
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