Toni Kroos will be unavailable for selection through injury, while Alvaro Odriozola has tested positive for coronavirus, but a number of the team's key players are now back in training ahead of the new season.
Karim Benzema was recently absent due to a positive coronavirus test, but the France international has now returned and should be available for this weekend's contest.
Eden Hazard's fitness has allegedly made a positive impression on the club's coaching staff this summer, and the Belgian could be in line for a starting role against Milan.
Elsewhere, there is likely to be a spot in the middle of the defence for new signing David Alaba, with Dani Carvajal, Nacho and Marcelo potentially making up the Spanish team's defence.
Martin Odegaard has remained with Real Madrid this summer despite the speculation surrounding his future, and he could line up in midfield alongside Luka Modric and Federico Valverde.
Gareth Bale is also available, having returned to the Bernabeu following a loan spell at Tottenham Hotspur, but Rodrygo might be given the nod to start alongside Benzema and Hazard as part of a front three.
Real Madrid possible starting lineup: Courtois; Carvajal, Alaba, Nacho, Marcelo; Modric, Valverde, Odegaard; Rodrygo, Benzema, Hazard
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