The defender suffered a hamstring injury when tackling Brest's Irvin Cardona at the weekend, and the challenge warranted a red card at first before VAR overturned the decision.
Luckily for Christophe Galtier, he has a well-rested Marquinhos ready to come back into the fold, and Kimpembe's injury should also see Danilo Pereira start in a three-man backline with Sergio Ramos.
Gianluigi Donnarumma was one of the heroes for PSG at the weekend after keeping out Islam Slimani's penalty, and he should keep Keylor Navas at bay once again.
Galtier may be tempted into a couple of changes out wide, with Nuno Mendes likely to displace Juan Bernat as Nordi Mukiele aims to demote Achraf Hakimi to the bench for the time being.
Renato Sanches is out with an adductor problem, but Galtier could still bring in Fabian Ruiz for Vitinha, who has been an ever-present of the engine room alongside Marco Verratti since his arrival.
The star-studded attacking line of Lionel Messi, Kylian Mbappe and Neymar has clicked into gear at the start of the new term, and the trio should all start on Wednesday.
PSG possible starting lineup: Donnarumma; Pereira, Marquinhos, Ramos; Mukiele, Verratti, Ruiz, Mendes; Messi; Mbappe, Neymar
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