Due to El Tri's lack of punch up front, coach Tata Martino - who will face his home nation this weekend - could be tempted to promote Raul Jimenez to the lineup in place of Henry Martin, who has scored just six times in 28 senior appearances for his country.
The Wolverhampton Wanderers striker, who has registered 29 goals at international level, made his first appearance since August in the Mexicans' final warm-up friendly and also played a part from the bench against opening-day opponents Poland in Qatar.
With Jesus Corona previously ruled out of the competition owing to injury, Alexis Vega and Napoli winger Hirving Lozano are set to remain the central striker's supporting cast from out wide.
La Seleccion mainstay Guillermo Ochoa celebrated his appearance at a fifth World Cup by saving Robert Lewandowski's penalty last time out, while fellow veteran Andres Guardado will hope to join him in achieving that feat at Lusail Stadium, after being consigned to the bench against Poland.
As Mexico prepare to co-host the next World Cup in 2026, a handful of fresh faces such as Pachuca midfielder Luis Chavez join two other members of the 100-cap club in an experienced first XI: Hector Herrera and Hector Moreno start once again.
Ajax pair Edson Alvarez and Jorge Sanchez should also be retained in Martino's 4-3-3 formation - in central midfield and at right-back respectively.
Mexico possible starting lineup: Ochoa; Sanchez, Montes, Moreno, Gallardo; Alvarez, Herrera, Chavez; Lozano, Martin, Vega