The experienced attacker was released from Portugal duty early and has been training alongside his new teammates this week, so a start against the Magpies this weekend is expected.
Jadon Sancho has recovered from the problem that forced him to pull out of the England squad, meanwhile, and the summer arrival could start alongside Ronaldo, Mason Greenwood and Bruno Fernandes as part of a front four against Steve Bruce's side.
Scott McTominay is back in training following groin surgery but will not be available this weekend, while Fred is banned due to a FIFA-imposed suspension after not joining up with the Brazil squad, so Donny van de Beek could be in line for a rare start alongside Paul Pogba in central midfield.
Marcus Rashford is still out as he recovers from a shoulder operation, but Alex Telles, Dean Henderson and Phil Jones have all returned to full training following their recent issues.
There are not expected to be any surprises between the sticks or in the back four, but head coach Ole Gunnar Solskjaer will need to assess the fitness of his returning international players before making a final call.
Nemanja Matic could yet be preferred to Van de Beek, while Solskjaer could also consider playing Pogba off the left depending on Sancho's fitness, with the Norwegian having plenty of options in the final third.
Manchester United possible starting lineup: De Gea; Wan-Bissaka, Varane, Maguire, Shaw; Van de Beek, Pogba; Greenwood, Fernandes, Sancho; Ronaldo