De Gea and Varane both missed out against Melbourne Victory on Friday due to minor issues, but the pair are expected to be back in the side for the team's third pre-season fixture of the summer.
Anthony Martial has now netted in back-to-back games against Liverpool and Melbourne Victory during the tour, and the Frenchman is again expected to start through the middle here, with Cristiano Ronaldo still absent for the 20-time English champions due to a personal issue.
Marcus Rashford could come back into the side, potentially replacing Anthony Elanga, to start alongside Martial and Jadon Sancho in a front three.
Head coach Erik ten Hag has made wholesale changes at the interval of both of the team's pre-season games this summer and that is again expected to be the case here.
Donny van de Beek and new signing Tyrell Malacia are perhaps the two players pushing hardest to break into the starting side, but it would not be a surprise to see both players again play the second period.
Zidane Iqbal and Charlie Savage have both impressed in their outings this summer, but there has not yet been a tour appearance for either Hannibal Mejbri or Alejandro Garnacho, while James Garner, who starred on loan at Nottingham Forest last season, has been unavailable for selection through injury.
Christian Eriksen was confirmed as Man United's second signing of the summer on Friday, but the Denmark international will not be heading out to Australia.
Manchester United possible starting lineup: De Gea; Dalot, Maguire, Varane, Shaw; McTominay, Fred; Rashford, Fernandes, Sancho; Martial