However, sentiment and rest for key players will also come into the Argentine's thinking as he takes several things into consideration.
Gaetano Berardi will end his long-term association with the club this summer, a development which could result in the Italian being handed a start in the middle of the backline.
While Pablo Hernandez is in the same position, the playmaker may have to make do with a place on the substitutes' bench.
Second-choice goalkeeper Kiko Casilla should keep his spot between the sticks after acting as Illan Meslier's deputy throughout this season.
Ahead of featuring in the England squad for Euro 2020, Kalvin Phillips could drop down to the bench with Pascal Struijk getting the nod as his replacement.
Tyler Roberts and Rodrigo Moreno may feature in an attack-minded quartet behind top goalscorer Patrick Bamford.
Given the recent success of the Under-23 squad, the likes of Sam Greenwood and Joe Gelhardt may be selected among the replacements.
Leeds United possible starting XI: Casilla; Ayling, Berardi, Cooper, Dallas; Struijk; Raphinha, Roberts, Rodrigo, Harrison; Bamford
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