With all the pressure on their shoulders ahead of the game, under-fire coach Max Allegri will be glad to welcome back experienced players such as the versatile Juan Cuadrado - who could replace Mattia De Sciglio at right-back - Paulo Dybala, Danilo and Alex Sandro.
That quartet - plus midfield regular Rodrigo Bentancur - could potentially feature, having returned too late from international duty to journey south with the squad to Naples at the weekend.
Influential Italy forward Federico Chiesa's participation remains in doubt because of a hamstring problem which arose on international duty, but Brazilian pair Kaio Jorge and Arthur are both sidelined for a while yet, with latter still recuperating after leg surgery.
If Chiesa continues to rest his injury, Allegri could be poised to pick Alvaro Morata and Moise Kean up front, though Sweden's Dejan Kulusevski could start out wide if the experienced tactician elects for a 4-3-3.
Former Roma and Cagliari left-back Luca Pellegrini started in the 2-1 reverse to Napoli, but after belatedly making his Juve debut after spells out on loan, the returning South Americans will most likely be favoured this time out.
At the back, the two central-defensive places will go to either Giorgio Chiellini or Leonardo Bonucci and probable starter Matthijs de Ligt.
Juventus possible starting lineup: Szczesny; Cuadrado, De Ligt, Bonucci, Sandro; McKennie, Locatelli, Rabiot; Kulusevski, Morata, Dybala