The Blues would secure their spot at next summer's European Championship if they are able to avoid defeat to third-placed Ukraine, who need to win to claim the runners-up spot behind England.
Italy were 5-2 winners over North Macedonia on Friday night, and it might be a case of same again for this match, with two-goal Federico Cheisa again featuring off the left.
Stephan El Shaarawy came off the bench to register late on in the team's last match, but Chiesa is set to be joined by Domenico Berardi and Giacomo Raspadori in the final third once again.
Jorginho, Nicolo Barella and Giacomo Bonaventura should continue as the midfield three, although Davide Frattesi is pushing to be included in that area of the field.
Federico Gatti made just his third appearance for the national side against North Macedonia and should continue in the middle of the defence alongside Francesco Acerbi.
There are also unlikely to be changes in the full-back positions, with Matteo Darmian and Federico Dimarco set to feature from the first whistle once again.
Italy possible starting lineup: Donnarumma; Darmian, Gatti, Acerbi, Dimarco; Barella, Jorginho, Bonaventura; Berardi, Raspadori, Chiesa