Coach Roberto Mancini has drawn criticism for demonstrating too much loyalty to his European Championship squad, which went unbeaten for well over a year, but is likely to make several changes following a humbling defeat to Argentina in Wednesday's 'Finalissima'.
Captain and long-serving defender Giorgio Chiellini now steps down from duty in the hosts' back four, so Inter centre-back Alessandro Bastoni will replace his Juventus counterpart alongside Leonardo Bonucci.
An integral part of Milan's recent Scudetto triumph, 22-year-old Sandro Tonali may also feature in midfield at Stadio Renato Dall'Ara, while Sassuolo's Gianluca Scamacca, 23, will hope to start ahead of Andrea Belotti up front.
Several players were missing for Mancini at Wembley - including midfield mainstay Marco Verratti, Serie A Capocannoniere Ciro Immobile, long-term injury victim Federico Chiesa and Scamacca's clubmate Domenico Berardi. Roma's injury-prone forward Nicolo Zaniolo is also unavailable.
Only the former could come into contention for a start in Bologna, if he recovers from injury in time to regain his place in a three-man midfield, in which Jorginho's place must be in serious doubt.
Uncapped midfielders Tommaso Pobega, Samuele Ricci and Davide Frattesi - the latter also of Sassuolo - are unlikely to start, but their appearance at some stage would herald the turning of a page in La Nazionale's recent history.
Italy possible starting lineup: Donnarumma; Di Lorenzo, Bonucci, Bastoni, Biraghi; Barella, Verratti, Tonali; Bernardeschi, Belotti, Insigne