The Nerazzurri lost Henrikh Mkhitaryan to a thigh injury in the second leg of their semi-final triumph against AC Milan last month, but there is optimism that the ex-Manchester United and Arsenal man will be given the green light to play.
The same also goes for Argentina attacker Joaquin Correa, who damaged his calf in Inter's Coppa Italia final win over Fiorentina in May, but the 28-year-old is unlikely to force his way into the first XI either way.
Indeed, Inzaghi has tended to place his faith in Lautaro Martinez and former Man City striker Edin Dzeko for significant showdowns such as this one, as Romelu Lukaku watches on from the bench again.
Should Mkhitaryan win his battle to be fit, Marcelo Brozovic's run in the first XI could come to an end, as the Armenian links up with Nicolo Barella and Hakan Calhanoglu in the middle.
Federico Dimarco is expected to recover from muscular fatigue in time to bomb down the left flank against Kyle Walker - a fascinating battle indeed - while Denzel Dumfries's spot on the right is not under any threat.
Aiming to match Edouard Mendy's record of nine Champions League clean sheets from 2020-21, Andre Onana ought to be protected by Alessandro Bastoni, Matteo Darmian and Francesco Acerbi, as the formerly indispensable Milan Skriniar and Stefan de Vrij take their places as substitutes ahead of expected summer departures.
Inter Milan possible starting lineup: Onana; Darmian, Acerbi, Bastoni; Dumfries, Barella, Mkhitaryan, Calhanoglu, Dimarco; Martinez, Dzeko