The Nasrids are already coping without Luis Milla, Domingos Duarte and Neyder Lozano, and recent reports have claimed that Rui Silva, Jesus Vallejo, German Sanchez and Carlos Neva are also occupying the treatment room, with the latter having to come off in the weekend's defeat to Sevilla.
Aaron Escandell is expected to get the nod in goal if Silva does miss out, while Martinez will surely revert to a back four as four of his centre-backs remain out of contention.
Nehuen Perez represents Granada's only fit centre-back at the minute, and right-back Victor Diaz is the most likely candidate to fill in alongside him, while Quini is expected to cover for Neva on the opposite flank.
Martinez has fewer concerns in midfield, with Maxime Gonalons and Yangel Herrera expected to retain their places, but Angel Montoro will miss out through suspension.
Antonio Puertas also collected his fifth yellow card of the campaign against Sevilla and will miss this one out, but Kenedy is expected to keep playing through the pain as he nurses an ankle injury.
Darwin Machis should deputise for the suspended Puertas in attack, while Luis Suarez is expected to provide the focal point despite Roberto Soldado's last-minute penalty at the weekend.
Granada possible starting lineup:
Escandell; Foulquier, Diaz, Perez, Quini; Gonalons, Herrera; Kenedy, Vico, Machis; Suarez
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