The Black Stars recorded a 3-2 victory over South Korea in their second match at the tournament, which has left them in second spot in Group H, boasting three points.
Ghana would definitely be through to the last-16 stage of the tournament if they beat Uruguay, while a draw would be enough providing that South Korea do not beat Portugal in the other game in the section.
Mohammed Kudus was the star of the show against South Korea last time out, finding the back of the net on two occasions, and he will again start for Ghana in this match.
Andre Ayew and Jordan Ayew are also expected to keep their spots in the positions behind Inaki Williams.
Thomas Partey is a certain starter in the middle of midfield, and he should again be joined by Salis Abdul Samed, who plays his club football for Lens.
There should be three Premier League representatives at the back in the shape of Brighton & Hove Albion's Tariq Lamptey, Southampton's Mohammed Salisu and Leicester City's Daniel Amartey, while Gideon Mensah should get the nod at left-back.
Kamaldeen Sulemana is another option in the final third of the field, but the 20-year-old is likely to be among the substitutes for the first whistle.
Ghana possible starting lineup: Ati-Zigi; Lamptey, Amartey, Salisu, Mensah; Partey, Samed; Kudus, A Ayew, J Ayew; Williams