After an injury-stricken first season in the Premier League with Everton, the midfielder was deemed unfit to feature in the Copa America, being left at home as a result.
Even in Rodriguez's absence, La Tricolor are not short of quality in midfield with Luis Diaz and Juventus' Juan Cuadrado operating on the wings while Diaz's Porto teammate Mateus Uribe will feature in the middle, supporting the two attackers.
He will be joined by tenacious Al-Hilal midfielder Gustavo Cuellar, who is known for his combative style and impressive tackling ability.
Meanwhile, the line should be led by Atalanta duo Luis Muriel and Duvan Zapata, with the pair having registered a combined 37 goals and 19 assists in Serie A this season, firing their side to an impressive third-placed finish.
At the other end of the pitch, Tottenham Hotspur centre-back Davinson Sanchez and Everton defender Yerry Mina will continue their established pairing at the heart of the back four.
They will shield experienced Napoli goalkeeper David Ospina, who has made 107 appearances for his nation.
Colombia possible starting XI: Ospina; Medina, Mina, Sanchez, Tesillo; Cuadrado, Cuellar, Uribe, Diaz; Zapata, Muriel
Monaco 
Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
Paris Saint Germain 
Toulouse 
CSKA Moscow 
FC Rostov 
Leicester 
Chelsea 
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
Lokomotiv Moscow 
Rangers 
Dundee Utd 
Atletico Madrid 
Alaves 
Lens 
Marseille 
Ingulets Petrove 
Shakhtar Donetsk 
AC Milan 
Juventus 
ST Malo 
Manchester City 
Tottenham 
Eintracht Frankfurt 
Werder Bremen 
Girona 
Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen