The Blues are on the hunt for a third successive win this weekend, having recently got the better of Luton Town and AFC Wimbledon in the league and EFL Cup respectively.
However, Pochettino is missing all of Romeo Lavia (fitness), Armando Broja (knee), Wesley Fofana (knee), Benoit Badiashile (thigh), Marcus Bettinelli (unspecified), Christopher Nkunku (knee), Carney Chukwuemeka (knee), Reece James (thigh), Mykhaylo Mudryk (unspecified) and Trevoh Chalobah (thigh) for the visit of the Tricky Trees, while Marc Cucurella could very well depart for Manchester United before the transfer window slams shut.
Despite giving away the penalty that enabled Wimbledon to take a shock lead in midweek, Robert Sanchez will continue in goal, and the same can be said for Axel Disasi and Levi Colwill at the back.
A well-rested Thiago Silva is in line to displace Bashir Humphreys, though, while the effervescent Malo Gusto and Ben Chilwell will return to their wing-back roles, as Cucurella and Noni Madueke make way.
Conor Gallagher's place in the engine room appears to be safe, but Lesley Ugochukwu and Ian Maatsen will no doubt cede their spots to £221m duo Moises Caicedo and Enzo Fernandez.
Diego Moreira's night against Wimbledon lasted all of 45 minutes, and the Portuguese youngster will now make way for a revitalised Raheem Sterling, while Nicolas Jackson demotes Mason Burstow to the dugout.
Chelsea possible starting lineup: Sanchez; Disasi, Colwill, Silva; Gusto, Fernandez, Caicedo, Gallagher, Chilwell; Sterling, Jackson