The Blues have several guaranteed absences for the capital contest, including Nicolas Jackson (international), Wesley Fofana (knee), Marc Cucurella (ankle), Robert Sanchez (knee), Trevoh Chalobah (thigh), Lesley Ugochukwu (hamstring), Reece James (hamstring) and Romeo Lavia (thigh).
Meanwhile, all of Christopher Nkunku (hip), Benoit Badiashile (unspecified), Ben Chilwell (thigh) and Carney Chukwuemeka (knee) are uncertain at the time of writing, having been forced to miss Tuesday's 1-0 EFL Cup semi-final first-leg loss to Middlesbrough.
With so few options for change at the minute, an unaltered backline should comprise Axel Disasi, Thiago Silva, Malo Gusto and Levi Colwill in front of Dorde Petrovic, unless Badiashile proves his fitness in time for the derby.
Moises Caicedo did not cover himself in glory whatsoever for Hayden Hackney's winner on Tuesday evening, and the Ecuadorian could very well find himself on the bench for Saturday's fixture if Conor Gallagher and Enzo Fernandez pair up in the middle.
A possible alteration in midfield would allow Mykhaylo Mudryk to provide an injection of pace into the attacking line, although Raheem Sterling and Cole Palmer - despite the latter's wastefulness in midweek - should hold their places.
Armando Broja was a notable omission from the first XI at Boro, a decision which Pochettino confirmed was related to his workload and previous fitness woes, but a recall to the starting lineup is ostensibly in order for the Albanian attacker.
Chelsea possible starting lineup: Petrovic; Gusto, Disasi, Silva, Colwill; Gallagher, Fernandez; Sterling, Palmer, Mudryk; Broja