Head coach Thomas Tuchel used Jorginho, Mason Mount, Andreas Christensen and Cesar Azpilicueta off the bench on Wednesday, and all four players could now come into the starting XI.
Thiago Silva might remain on the bench for the European Cup winners, while Ben Chilwell and Reece James could also be among the substitutes against Palace.
As a result, Callum Hudson-Odoi and Marcos Alonso could continue as the two wing-backs, with Jorginho joining N'Golo Kante in the middle of the park.
Ziyech's absence will open the door for Mount to join Timo Werner and Kai Havertz in the final third of the field, leaving Christian Pulisic on the bench.
Romelu Lukaku is expected to be confirmed as a Chelsea player before kickoff this weekend, but the Belgium international is only likely to be on the bench if he is indeed involved.
There are not expected to be any serious surprises in the home side's XI at Stamford Bridge, and Tuchel is unlikely to move away from a 3-4-3 formation, but Kurt Zouma, Mateo Kovacic and Trevor Chalobah are likely to drop out from the starting team on Wednesday evening.
Chelsea possible starting lineup: Mendy; Azpilicueta, Christensen, Rudiger; Hudson-Odoi, Kante, Jorginho, Alonso; Mount, Werner, Havertz