With the Blaugrana able to rise to the summit with a win, Koeman remains without long-term absentees Ansu Fati and Philippe Coutinho, while Martin Braithwaite is expected to miss another couple of weeks with an ankle problem.
However, none of the trio would be expected to displace Antoine Griezmann or Lionel Messi up top, while Ousmane Dembele should also be restricted to another substitute outing.
Griezmann will be out to score for the fourth game in a row after his brace against Villarreal, while his in-form partner Messi boasts nine goals and three assists from six Camp Nou games against Granada in La Liga.
Pedri and Frenkie de Jong will continue to man the engine room as Sergio Busquets provides some defensive stability, but one change on the right could see Sergi Roberto replace Sergino Dest - as he did at half time in the win over Villarreal.
Oscar Mingueza, Clement Lenglet and Gerard Pique have formed an effective back three in recent weeks, meaning that Ronald Araujo should keep the bench warm with fit-again backup goalkeeper Neto.
Barcelona possible starting lineup:
Ter Stegen; Mingueza, Lenglet, Pique; Busquets; Roberto, De Jong, Pedri, Alba; Messi, Griezmann
> Click here to see how Granada could line up for this clash