The Catalan giants, who are currently third in the table, four points off leaders Atletico Madrid, will again be without the services of Philippe Coutinho and Ansu Fati this weekend due to long-term knee injuries.
Sergi Roberto has also been ruled out of the contest due to a thigh problem, while Frenkie de Jong is suspended following his yellow card in the 3-3 draw with Levante last time out.
Sergino Dest is in line to return to the starting XI, but Oscar Mingueza is expected to feature for the B side in their promotion playoff against UCAM Murcia on Sunday, meaning that Ronald Araujo should keep his spot at the back.
Head coach Ronald Koeman could ultimately decide to change his formation this weekend, with Ousmane Dembele joining Lionel Messi and Antoine Griezmann as part of a front three.
There is the option of bringing Riqui Puig, Ilaix Moriba or Miralem Pjanic into midfield alongside Pedri and Sergio Busquets, but Koeman might feel that attack is the best form of defence in this match.
As a result, it is likely to be a 3-4-3 formation for Barca, who need to win both of their final games against Celta and Eibar and hope that Atletico and second-placed Real Madrid slip up.
Barcelona possible starting lineup: Ter Stegen; Araujo, Pique, Lenglet; Dest, Busquets, Pedri, Alba; Griezmann, Messi, Dembele
> Click here to see how Celta could line up for this contest