The Paris Saint-Germain attacker led by example in Saturday's win over Panama, scoring his side's second with a trademark free kick on a night of unbridled celebration.
Messi's set-piece strike marked his 800th career goal, and the 35-year-old ought to continue in the final third, with just one more effort needed to bring up a century for the national team.
Lionel Scaloni named the same starting lineup from the World Cup final in Buenos Aires, but the 44-year-old may now ring the changes as Paulo Dybala and Lautaro Martinez eye starts in the final third.
Thiago Almada came off the bench to break the deadlock with 78 minutes gone against Panama, and the 21-year-old could now be rewarded with a first senior start for his country.
Leandro Paredes and Exequiel Palacios may join Almada in the engine room, as Marcos Acuna and Gonzalo Montiel provide fresh legs in the full-back areas.
Lisandro Martinez and German Pezzella represent alternative centre-back options, while number one Emiliano Martinez could be given the night off as Geronimo Rulli enjoys a run-out.
Argentina possible starting lineup: Rulli; Montiel, Pezzella, Li. Martinez, Acuna; Almada, Paredes, Palacios; Messi, La. Martinez, Dybala