After a patched-up side lost to Spezia at the weekend, the Rossoneri should recall captain Davide Calabria and centre-forward Olivier Giroud, while beleaguered coach Stefano Pioli will be praying Rafael Leao can return to fitness in time to play in a such crucial Milan derby.
The latter has been back in full training but might not be risked from the start, in which case either Alexis Saelemaekers or Junior Messias - who faces his own fitness battle - could fill in.
Returning from a Serie A suspension, Malick Thiaw can fight it out with Simon Kjaer to partner Fikayo Tomori at the heart of Milan's defence, while Rade Krunic is expected to start in midfield alongside Sandro Tonali, despite being sidelined by a knee problem on Saturday.
Krunic's comeback would be well timed, as Ismael Bennacer saw his season ended by a serious knee injury sustained last week; Alessandro Florenzi is also unavailable.
Pierre Kalulu, Ante Rebic and Champions League specialist Divock Origi are all set to be dropped following the dismal display in La Spezia. However, Origi may be called upon if Leao cannot play.
AC Milan possible starting lineup: Maignan; Calabria, Tomori, Kjaer, Hernandez; Tonali, Pobega; Diaz, Krunic, Saelemaekers; Giroud
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