Following a 3-2 defeat in last week's group opener against Portugal, the Black Stars got their campaign back on track four days later as they claimed a hard-fought 3-2 victory over South Korea at the Education City Stadium.
While Otto Addo's side sit second in the group and in pole position to finish as runners-up, Uruguay have picked up just one point from a possible six and need nothing less than a win to keep their slim qualification hopes alive.
Here, Sports Mole looks at how the squad of Ghana and Uruguay stack up against each other ahead of Friday's contest.
GHANA
Most valuable player:
Thomas Partey (£32.8m)
Overall squad value:
£187.5m
Most capped player:
Andre Ayew (112)
Leading goalscorer:
Andre Ayew (24)
Total caps:
483
Total goals:
73
Oldest player:
Denis Odoi (34)
Youngest player:
Abdul Fatawu Issahaku (18)
Average age:
24.7
SQUAD IN FULL
Goalkeepers: Lawrence Ati-Zigi (St Gallen), Ibrahim Danlad (Asante Kotoko), Abdul Manaf Nurudeen (Eupen)
Defenders: Joseph Aidoo (Celta Vigo), Daniel Amartey (Leicester City), Abdul Rahman Baba (Reading), Alexander Djiku (Racing Strasbourg), Tariq Lamptey (Brighton & Hove Albion), Gideon Mensah (Auxerre), Denis Odoi (Club Bruges), Mohammed Salisu (Southampton), Alidu Seidu (Clermont)
Midfielders: Mohammed Kudus (Ajax), Daniel-Kofi Kyereh (Freiburg), Elisha Owusu (Gent), Thomas Partey (Arsenal), Salis Abdul Samed (Lens)
Forwards: Daniel Afriyie (Hearts of Oak), Andre Ayew (Al Sadd), Jordan Ayew (Crystal Palace), Osman Bukari (Red Star Belgrade), Issahaku Abdul Fatawu (Sporting Lisbon), Antoine Semenyo (Bristol City), Kamal Sowah (Club Bruges), Kamaldeen Sulemana (Rennes), Inaki Williams (Athletic Bilbao)
URUGUAY
Most valuable player:
Federico Valverde (£86.2m)
Overall squad value:
£388m
Most capped player:
Diego Godin (161)
Leading goalscorer:
Luis Suarez (68)
Total caps:
1214
Total goals:
173
Oldest player:
Diego Godin (36)
Youngest player:
Facundo Pellistri (20)
Average age:
27.8
SQUAD IN FULL
Goalkeepers: Fernando Muslera (Galatasaray), Sergio Rochet (Nacional), Sebastian Sosa (Independiente)
Defenders: Diego Godin (Velez Sarsfield), Jose Gimenez (Atletico Madrid), Martin Caceres (LA Galaxy), Sebastian Coates (Sporting Lisbon), Matias Vina (Roma), Ronald Araujo (Barcelona), Guillermo Varela (Flamengo), Mathias Olivera (Napoli), Jose Luis Rodriguez (Nacional)
Midfielders: Matias Vecino (Lazio), Rodrigo Bentancur (Tottenham Hotspur), Federico Valverde (Real Madrid), Giorgian de Arrascaeta (Flamengo), Lucas Torreira (Galatasaray), Nicolas de la Cruz (River Plate), Manuel Ugarte (Sporting)
Forwards: Luis Suarez (Nacional), Edinson Cavani (Valencia), Maxi Gomez (Trabzonspor), Darwin Nunez (Liverpool), Facundo Torres (Orlando City), Facundo Pellistri (Manchester United), Agustin Canobbio (Athletico Paranaense)
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