Hansi Flick believes "everyone should get vaccinated" after five of his Germany players were forced into quarantine.
The Germans are preparing to host Liechtenstein in a World Cup qualifier in Wolfsburg, but have seen their preparations affected.
Bayern Munich's Niklas Sule has tested positive for Covid-19 which has forced him and four of his teammates into quarantine.
The centre-half, who has been vaccinated as has been confirmed by the German Football Association, will quarantine alongside four of the eight players he travelled to Wolfsburg with - Bayern Munich trio Joshua Kimmich, Serge Gnabry and Jamal Musiala, plus Red Bull Salzburg's Karim Adeyemi
The other four, who have not been named by the German FA (DFB), will remain with the squad under "special supervision," eating at an isolated table and being tested regularly.
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Following the outbreak Flick has made his feelings clear on the virus and defending against it.
"We are allowed to play football, and we have a responsibility to ensure that we are all healthy, either by way of vaccinations or regular testing," he said.
"Nevertheless, vaccinations are not mandatory and we shouldn't judge those who have not yet been vaccinated because they have concerns.
"I am personally of the opinion that everyone should get vaccinated but, as long as it's not mandatory, everyone has the right to not do it."
Germany team manager Oliver Bierhoff said earlier this week that the World Cup qualifier against Liechtenstein will have special measures put in place to ensure safety.
"The number of corona infections nationwide has recently risen sharply again," he said.
"That's why we're putting in place a new program during the last international match of the year: We are continuing to implement hygiene and behavioral rules during the last international match of the year in order to act as responsibly as possible."
Kimmich, a regular for club and country, recently confirmed reports that he was yet to get the vaccine.
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"I have concerns about the lack of long-term studies," he told Sky Sports.
"I am of course aware of my responsibility. I follow all hygiene measures and get tested every two to three days. Everyone should make the decision for themselves."
He then addressed criticism that has come his way: "I find it a shame that there is only vaccinated and unvaccinated in this debate. Unvaccinated then seems to equal COVID denier or anti-vaxxer.
"But there are other people who just have concerns, whatever their reasons, and I think we should respect that as long as they also stick to the measures."