Arsenal and Manchester United have already been victims of cup upsets, with the likes of Boreham Wood, Peterborough and Luton Town still in the historic competition.
A total of 16 teams will take place in the fifth round of the FA Cup as they start to dream about a trip to Wembley Stadium in May.
Here talkSPORT.com takes a look at everything that you need to know ahead of the next round of the competition.
FA Cup quarter-final draw: Date and start time
The quarter-final draw will take place on Thursday, March 3.
The draw will be broadcast live on ITV at around 7.45pm before the fifth-round game between Everton and Boreham Wood.
Fans can also live stream this via the ITV Hub app using their mobile, tablet or computer devices.
FA Cup quarter-final draw: Ball Numbers
The ball numbers for the draw will be confirmed soon and here are the fifth-round ties set to be played.
Luton Town vs Chelsea - live on talkSPORT
Crystal Palace vs Stoke City
Peterborough United vs Manchester City - talkSPORT exclusive
Liverpool vs Norwich City - live on talkSPORT 2
Southampton vs West Ham United
Middlesbrough vs Tottenham Hotspur - live on talkSPORT 2
Nottingham Forest vs Huddersfield Town
Everton vs Boreham Wood - live on talkSPORT
FA Cup quarter-final draw: Tournament schedule
Fifth Round: Tuesday, March 1 - Monday, March 7
Quarter-Final: Saturday, March 19
Semi-Final: Saturday, April 16
Final: Saturday, May 14