Gustavo Alfaro's men currently sit second in Group A with four points from two games, and a draw in their final group outing will see them progress into the last 16.
Aliou Cisse's men, on the other hand, need all three points tomorrow to confirm their qualification into the next round, although a draw could also suffice depending on what happens in the other group fixture between the Netherlands and Qatar.
Here, Sports Mole looks at how the squads of Ecuador and Senegal weigh up against each other ahead of Tuesday's matchup.
ECUADOR
Most valuable player:
Moises Caicedo (£33.1m)
Overall squad value:
£127.5m
Most capped player:
Enner Valencia (75)
Leading goalscorer:
Enner Valencia (38)
Total caps:
657
Total goals:
77
Oldest player:
Hernan Galindez (35)
Youngest player:
Jeremy Sarmiento (20)
Average age:
25.6
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Goalkeepers: Alexander Dominguez (Deportes Tolima), Hernan Galindez (Aucas), Moises Ramirez (Independiente)
Defenders: Robert Arboleda (Sao Paulo), Xavier Arreaga (Seattle Sounders), Pervis Estupinan (Brighton), Piero Hincapie (Bayer Leverkusen), William Pacho (Royal Antwerp), Diego Palacios (LAFC), Jackson Porozo (Troyes), Angelo Preciado (Genk), Felix Torres (Santos Laguna)
Midfielders: Moises Caicedo (Brighton), Jose Cifuentes (LAFC), Alan Franco (Talleres), Carlos Gruezo (Augsburg), Jhegson Mendez (LAFC), Ayrton Preciado (Santos Laguna), Jeremy Sarmiento (Brighton)
Forwards: Michael Estrada (Cruz Azul), Romario Ibarra (Pachuca), Angel Mena (Club Leon), Gonzalo Plata (Real Valladolid), Djorkaeff Reasco (Newell's Old Boys), Kevin Rodriguez (Imbabura SC), Enner Valencia (Fenerbahce)
SENEGAL
Most valuable player:
Kalidou Koulibaly (£30.4m)
Overall squad value:
£199.3m
Most capped player:
Idrissa Gueye (98)
Leading goalscorer:
Famara Diedhiou (11)
Total caps:
574
Total goals:
42
Oldest player:
Idrissa Gueye (33)
Youngest player:
Pape Matar Sarr (20)
Average age:
25.9
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Goalkeepers: Edouard Mendy (Chelsea), Alfred Gomis (Rennes), Seny Dieng (Queens Park Rangers)
Defenders: Kalidou Koulibaly (Chelsea), Fode Ballo-Toure (AC Milan), Pape Abou Cisse (Olympiacos), Youssouf Sabaly (Real Betis), Ismail Jakobs (Monaco), Formose Mendy (Amiens), Abdou Diallo (RB Leipzig), Moussa N'Diaye (Anderlecht)
Midfielders: Idrissa Gueye (Everton), Nampalys Mendy (Leicester City), Cheikhou Kouyate (Nottingham Forest), Pathe Ciss (Rayo Vallecano), Krepin Diatta (Monaco), Pape Matar Sarr (Tottenham Hotspur), Moustapha Name (Pafos), Mamadou Loum (Reading), Pape Gueye (Marseille)
Forwards: Nicolas Jackson (Villarreal), Boulaye Dia (Salernitana), Ismaila Sarr (Watford), Famara Diedhiou (Alanyaspor), Bamba Dieng (Marseille), Iliman Ndiaye (Sheffield United)
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How Senegal could line up against Ecuador