Meetings between the clubs have been few and far between, but when they have met, there has been a lot on line, with all of them coming in the most elite UEFA competitions.
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between BVB and Barca.
Head-to-head record
Previous meetings: 4
Dortmund wins: 0
Draws: 2
Barcelona wins: 2
In the four meetings between the two powerhouses of their respective nations, Dortmund have never managed to get the better of Barcelona.
That is despite going into the 1997-98 UEFA Super Cup as the Champions League holders, where they would face UEFA Cup winners Barca.
Back when it was held in mid-season over two legs, Dortmund fell to a 2-0 defeat at the Nou Camp, thanks to Luis Enrique's opener and a Rivaldo penalty.
All was not lost heading into the second leg, but an early goal by Giovanni at the Westfalenstadion put the tie beyond BVB, with Jorg Heinrich's consolation meaning very little as Barca took the trophy, winning 3-1 on aggregate.
The two did not meet again for over two decades, until they were drawn in the same Champions League group in 2019, and they would face off on the opening night, and on matchday five.
An underwhelming Barca side under Ernesto Valverde managed just one shot on target in the away fixture, and were lucky to escape with a 0-0 draw after Marco Reus missed a second-half penalty for the German side.
In the return fixture, Barca were much more convincing, sweeping Dortmund aside 3-1 with goals coming from their front three of Luis Suarez, Lionel Messi and Antoine Griezmann, while Jadon Sancho netted a late consolation.
The game was of little consequence to the makeup of the group, as both Barca and Dortmund progressed ahead of Inter Milan, but the Catalan side would go on to be embarrassed 8-2 by BVB's rivals Bayern Munich in the single-legged quarter-final.
Previous meetings
Nov 27, 2019: Barcelona 3-1 Dortmund (Champions League Group Stage)
Sep 17, 2019: Dortmund 0-0 Barcelona (Champions League Group Stage)
Mar 11, 1998: Dortmund 0-0 Barcelona (UEFA Super Cup Final Second Leg)
Jan 08, 1998: Barcelona 2-0 Dortmund (UEFA Super Cup Final First Leg)
Previous Champions League meetings
Nov 27, 2019: Barcelona 3-1 Dortmund (Group Stage)
Sep 17, 2019: Dortmund 0-0 Barcelona (Group Stage)
Written by
Andrew Delaney