The Red Devils are currently seventh in the table, two points behind sixth-placed Newcastle United, while Palace occupy 14th position, and here Sports Mole rounds up the team news.
CRYSTAL PALACE vs. MANCHESTER UNITED
CRYSTAL PALACE
Out: Sam Johnstone (elbow), Cheick Doucoure (calf), Jefferson Lerma (thigh), Rob Holding (thigh), Matheus Franca (groin)
Doubtful: None
Sports Mole's predicted XI: Henderson; Clyne, Andersen, Richards; Munoz, Wharton, Hughes, Mitchell; Olise, Mateta, Eze
MANCHESTER UNITED
Out: Tyrell Malacia (knee), Lisandro Martinez (calf), Raphael Varane (muscle), Luke Shaw (thigh), Anthony Martial (groin), Marcus Rashford (unspecified), Victor Lindelof (thigh), Willy Kambwala (unspecified), Harry Maguire (muscle)
Doubtful: Bruno Fernandes (unspecified), Scott McTominay (knee), Jonny Evans (muscle)
Sports Mole's predicted XI: Onana; Wan-Bissaka, Casemiro, Evans, Dalot; McTominay, Mainoo; Antony, Fernandes, Garnacho; Hojlund
For data analysis of the most likely results, scorelines and more for this match please click here.