Tottenham have been superb so far this season and went into the international break top of the table with three wins from three.
Palace are yet to win in the league this term under new boss Patrick Vieira and drew at West Ham last time out.
The Eagles haven't beaten Spurs in the Premier League since January 2015.
talkSPORT will be at the Tottenham Hotspur Stadium to bring you all the action.
Crystal Palace v Tottenham: How to listen
This match will kick-off at 12:30pm on Saturday, September 11.
Reshmin Chowdhury will be your host and commentary will come from Clive Tyldesley and Dean Ashton.
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Crystal Palace v Tottenham Team News
Palace are still without some of their star players including Eberechi Eze and Nathan Ferguson.
Michael Olise is yet to feature for the Eagles but could be back to action after this match.
Meanwhile, Luka Milivojevic could feature in the squad but fitness is still a concern.
Patrick Vieira will hope for no new injury concerns as the international break comes to a end.
Tottenham will be likely be without their Argentina stars Cristian Romero and Giovani Lo Celso following the controversy that surrounded their match with Brazil.
Joe Rodon is also set to miss the return to club football after the international break after picking up a knock.
Aside from those, Spurs will be hoping to put a full-strength side out around their core squad absentees from Argentina.
Crystal Palace v Tottenham: Match stats and fact
Crystal Palace are winless in their last 12 Premier League meetings with Spurs (D2 L10) since a 2-1 win in January 2015. The Eagles have scored just four goals in this run, failing to find the net on eight occasions.
Tottenham have only failed to score in one of their 12 Premier League away games against Crystal Palace (W7 D3 L2), doing so in a 3-0 defeat in January 2005. Spurs have netted exactly once in each of their last five league games at Selhurst Park.
Crystal Palace are set to become the first side to start a top-flight campaign with four consecutive London derbies. However, the Eagles are winless in their last 11 such games in the Premier League (D6 L5).
Tottenham have started a league campaign with three wins and three clean sheets for the first time in their history. Only four teams have ever begun a top-flight campaign with four wins and no goals conceded - Aston Villa in 1900-01, Ipswich Town in 1974-75, Chelsea in 2005-06 and Manchester City in 2015-16.
Crystal Palace have managed fewer shots (20) and fewer shots on target (5) than any other team in the Premier League this season. However, the Eagles did score with both of their efforts on target last time out against West Ham.
Tottenham are looking to win five consecutive Premier League games for the first time since December 2018 under Mauricio Pochettino. However, Spurs have lost three of their last five Premier League London derbies (W2), as many as they had in their previous 16 such games in the competition (W6 D7).
Conor Gallagher scored both of Crystal Palace's goals against West Ham last time out, having netted just twice in his previous 31 Premier League appearances combined.
Tottenham striker Harry Kane has scored 38 goals in Premier League London derby matches, second only to Thierry Henry (43) in the competition. Kane has been involved in 12 goals in 14 Premier League games against Crystal Palace (7 goals, 5 assists), including six in seven at Selhurst Park.
Crystal Palace's Wilfried Zaha has faced Tottenham more often without registering a single goal or assist than he has any other side in the competition (12).
Since the start of last season, no player has scored more winning goals in the Premier League than Tottenham's Son Heung-min (8), with both of the Korean's strikes so far this season proving decisive.