The Italian leaves out Tanguy Ndombele but starts with an attack that contains Harry Kane and Heung-Min Son.
As he did against Vitesse, Conte lines his players up in a 3-4-3 formation again as he aims to get off to the perfect start in his first league match.
Given Spurs' lack of goals this season, it was an encouraging start for Conte who saw his side race into a 3-0 lead after 30 minutes.
However he was made to sweat for large parts of the match as the visitors nearly mounted a comeback.
Thankfully for the Italian though his players managed to see out the match and secure a morale boosting victory after what has been a difficult start to the season.
Whilst he fields an extremely exciting looking line-up, he will face a tough task to break down an Everton side who are also in need of a good result after a series of defeats.
Given Rafael Benitez's history, he will make sure that his team are hard to beat.
It remains to be seen whether Conte can secure his first win in the Premier League as Spurs boss, but given his record, he will be optimistic.
In five matches as Chelsea boss, he oversaw his team to four wins one which included a 5-0 drubbing at Stamford Bridge.
However, his record with Benitez is a little closer than he would like, also in five matches Conte currently leads the Spaniard 3-2 and will hope he can extend that today.
Everton line up
Pickford, Coleman (C), Godfrey, Keane, Digne, Gordon, Delph, Allan, Townsend, Richarlison, Gray
Substitutes: Kenny, Holgate, Begovic, Iwobi, Tosun, Gbamin, Davies, Branthwaite, Rondon
Tottenham Hotspur line up
Lloris (C), Romero, Dier, Davies, Emerson, Hojbjerg, Skipp, Reguilon, Lucas Moura, Son, Kane.
Substitutes: Doherty, Sanchez, Winks, Lo Celso, Alli, Gollini, Bergwijn,
Tanganga, Ndombele