The Blues beat Zenit Saint-Petersburg in their opening European tie this season but lost at Juventus last time out.
Thomas Tuchel's men need to keep touch with Juve at the top of the group and can afford no mistakes against Swedish champions Malmo.
Chelsea are on a run of favourable fixtures and will want to kick on domestically and in Europe ahead of the hectic festive period.
The west Londoners face a quick turnaround for their next match as they host Norwich in the Premier League on Saturday lunchtime.
Chelsea v Malmo: Date and kick-off time
This Group H tie is due to take place on Wednesday, October 20.
It is taking place at Stamford Bridge and kick-off is at 8pm.
These two sides have met once before - in the Round of 32 of the 2018/19 Europa League. Chelsea won the tie 5-1 on aggregate and went on to beat Arsenal in the final.
Chelsea v Malmo: TV channel and live stream
The Champions League clash will be live on BT Sport 3 with coverage starting at 7:15pm.
BT Sport subscribers can live stream this match via the app on their computer, mobile and tablet devices.
talkSPORT's Adrian Durham will bring you updates from this match on Kick-Off 'Around the Grounds'.
talkSPORT.com will also be running a live blog for all the action.
Chelsea v Malmo: Team news
Thiago Silva and Antonio Rudiger have bolstered Chelsea's defensive options ahead of the visit of Malmo.
The centre-back pair missed Saturday's 1-0 Premier League win at Brentford, but were both back in training on Monday.
Experienced centre-back Silva only returned from Brazil duty on Friday afternoon, leaving the 37-year-old short of preparation time for the Brentford trip.
Germany defender Rudiger picked up a minor back issue on national team duty and was forced to sit out the Blues' gritty win on the road.
Hakim Ziyech could return to action but Christian Pulisic remains out.
Chelsea v Malmo: What has been said?
Chelsea boss Thomas Tuchel: "In general Malmo are a team that is confident. Still they have a certain style and they trust it.
"We absolutely should not underestimate them. We respect them as much as any team.
"They are a very successful coach, it is a team that trusts its own style.
"I remember having a very nice holiday in Stockholm - beautiful city, it was a very relaxing holiday. Scandinavian style of living, of thinking outside the box is very impressive and something you feel in their approach in sport.
"When you play them you feel they are confident, not shy of trying new ways to reach their personal best level. It is always inspiring."