The Blues fell to a surprise 3-2 defeat against West Ham last Sunday and they'll be determined to get back to winning ways this time around.
As for Leeds, they'll be hoping to continue their recent encouraging form.
A win and two draws from their last three games has seen Marcelo Bielsa's side move six points clear of the relegation zone and so they'll be determined to kick on and push towards the top half before long.
Doing so in West London, however, could be tricky.
Chelsea v Leeds United: Date and kick-off time
The Premier League clash is due to take place on Saturday, December 11 and will take place at Stamford Bridge, London.
Kick-off is scheduled for 3pm UK time.
Chelsea will be looking to get back to winning ways following their defeat to London rivals West Ham last weekend.
Chelsea v Leeds United: talkSPORT coverage
Coverage will get underway at 2.30pm with commentary coming from Ian Danter and former Arsenal winger Perry Groves.
talkSPORT will have updates throughout the day and you can listen through our radio player below
Chelsea v Leeds United: Team news
Thomas Tuchel will be without several players for the clash at Stamford Bridge.
Ben Chillwell, N'Golo Kante and Trevoh Chalobah are missing through injury, while Mateo Kovacic is out with COVID-19.
Jorginho could return while Timo Werner and Romelu Lukaku will be pushing for a start.
Marcelo Biela could be without several high-profile players.
Rodrigo and Robin Koch are set to miss out while Patrick Bamford, Kalvin Phillips and Liam Cooper are all likely to miss out.
Chelsea v Leeds United: What has been said?
Marcelo Bielsa: "Each of the games that we're going to face, they're all games where points are at stake, whether that be drawing or winning.
"We prepare ourselves with a lot of hope.
"The hopes and the desires are increased because they are very big opponents. And to be able to get points in those games has an added value. And we're going to go each of those games with that desire."
Chelsea v Leeds United: Match facts
Chelsea have won their last four home league games against Leeds - they've never won five in a row against them at Stamford Bridge.
Leeds are winless in their last six meetings with Chelsea in all competitions (D2 L4), since a 2-0 home win in December 2002.
In all competitions, Leeds have lost their last seven meetings with reigning European champions, since beating Nottingham Forest 1-0 in December 1980. Their last such game was a 5-1 home defeat to Chelsea in a League Cup tie in December 2012.
Chelsea have drawn their last two home Premier League matches, 1-1 draws with Burnley and Manchester United. The Blues haven't drawn three in a row at Stamford Bridge since a run of four between December 2015 and February 2016 under Guus Hiddink.
Chelsea conceded more than twice for just the second time in 34 Premier League games under Thomas Tuchel in their 3-2 loss at West Ham last time out. In fact, the Blues have conceded more goals in their last three Premier League games (5) than they had in their first 12 combined this season (4).
Leeds have won just two of their last 32 away matches in London in all competitions (D7 L23) and have lost two of their last three games when scoring first in the capital: against Chelsea last December and Spurs in November (won 2-1 in the other vs Fulham).
Both Chelsea and Leeds have scored a joint league-high three goals in the 90th minute of Premier League games this season; Chelsea's three have put the gloss on already won games for them, while Leeds' three have either been winning (1) or equalising (2) strikes.
Mason Mount has both scored and assisted a goal in three of his last four Premier League starts for Chelsea, with the English midfielder scoring five and assisting three in these games. Mount has the most league goals (9) and assists (6) of any Chelsea player under Thomas Tuchel.
Raphinha has scored six of Leeds' 15 Premier League goals this season, with no other player at the club netting more than twice so far this term. His six goals have been worth seven points to the Whites, with only Jamie Vardy's strikes being more valuable to his side this season (8).
Patrick Bamford - who scored in Leeds' 3-1 defeat at Chelsea last season - is looking to become the first Leeds player to score in consecutive away league matches against Chelsea since Gary McAllister in the 1994-95 and 1995-96 seasons.