The Blues have picked up just one point from two home fixtures against Arsenal and Brentford since the October international break, leaving them in the bottom half of the standings.
However, they warmed up for their upcoming showdown with the top-flight leaders by overcoming Blackburn Rovers in the EFL Cup fourth round on Wednesday night.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of their short trip to the Tottenham Hotspur Stadium.
Ben Chilwell
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Ben Chilwell remains on the sidelines for Chelsea due to a hamstring issue, and it is unlikely that the England international will be back on the field until December.
Christopher Nkunku
Status: Out
Type of injury: Knee
Possible return date: Unknown
While Pochettino has recently provided a positive update on Christopher Nkunku, the France international will not return before the international break.
Wesley Fofana
Status: Out
Type of injury: Knee
Possible return date: Unknown
Wesley Fofana faces a battle to return before the end of the 2023-24 campaign, with the Frenchman undergoing a knee operation in the middle of July.
Trevoh Chalobah
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Trevoh Chalobah is yet to feature this season due to a troublesome thigh problem, and the defender will again be unavailable for selection for this fixture.
Carney Chukwuemeka
Status: Out
Type of injury: Knee
Possible return date: Unknown
Carney Chukwuemeka has suffered a recurrence of a previous knee injury, and the midfielder is now expected to be on the sidelines until at least after the November international break.
Romeo Lavia
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Romeo Lavia is yet to make his debut for Chelsea due to a lack of fitness and an ankle problem, and the midfielder will remain absent until after the November international break.
Marcus Bettinelli
Status: Out
Type of injury: Unspecified
Possible return date: Unknown
Marcus Bettinelli has not made a matchday squad this season due to an unspecified injury, and it is unclear when the experienced goalkeeper could be available for selection once again.
Armando Broja
Status: Out
Type of injury: Knee
Possible return date: Unknown
Armando Broja has been absent since the October international break due to a fresh knee issue, and it appears highly unlikely that the Albania international will return before November's equivalent.
Mykhaylo Mudryk
Status: Minor doubt
Type of injury: Muscle
Possible return date: November 6 (vs. Tottenham Hotspur)
While Mykhaylo Mudryk has been missing for the last two matches with a minor muscle strain, he could return to the squad against Spurs.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspension issues for this match.