Hayden Hackney scored the only goal of the match, as Michael Carrick's side beat Chelsea by a single goal in the first leg of their last-four contest on January 9.
Mauricio Pochettino's side will now be looking to use home advantage to navigate their way into the final, and the capital giants will enter the match off the back of a 1-0 win over Fulham in the Premier League.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of their clash with Middlesbrough, who sit 10th in the Championship table.
Christopher Nkunku
Status: Out
Type of injury: Hip
Possible return date: Unknown
Nkunku has only just returned from a serious knee injury, which delayed his Chelsea debut until December 24, but he is now suffering with a hip problem, and he will again miss out here.
Wesley Fofana
Status: Out
Type of injury: Knee
Possible return date: Unknown
Fofana is not expected to be available for selection until next season, with the centre-back being forced to undergo an operation on a severe knee injury over the summer.
Trevoh Chalobah
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Chalobah is still struggling to overcome a thigh problem, and the centre-back will again be unavailable for selection against Middlesbrough.
Lesley Ugochukwu
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Ugochukwu suffered a hamstring injury during Chelsea's loss to Wolverhampton Wanderers last month, and the midfielder is not expected to be back until February.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
James is currently on the sidelines recovering from a hamstring operation, and it is unlikely that the Chelsea captain will be back on the field until the end of March.
Robert Sanchez
Status: Out
Type of injury: Knee
Possible return date: January 31 (vs. Liverpool)
Sanchez remains unavailable due to a knee injury, but the club's number one goalkeeper has a chance of being available for selection for the clash with Liverpool at the end of the month.
Marc Cucurella
Status: Out
Type of injury: Ankle
Possible return date: March 2 (vs. Brentford)
Cucurella is currently battling his way back from a severe ankle problem, and it is unlikely that the Spaniard will be available until the start of March.
Romeo Lavia
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Lavia made his Chelsea debut in December against Crystal Palace after recovering from an ankle issue, but the summer arrival is currently out with a thigh problem.
Nicolas Jackson
Status: Out
Reason of absence: International duty
Possible return date: Unknown
Jackson is representing Senegal at the Africa Cup of Nations, so the striker will not be available for selection until his country have been knocked out or the competition has finished.
CHELSEA'S SUSPENSION LIST
Chelsea have no players suspended for this match.