The Blues claimed a 4-1 away victory against a nine-man Spurs outfit in a chaotic contest on Monday, with a Cole Palmer equaliser from the penalty spot and a second-half hat-trick from Nicolas Jackson ensuring Mauricio Pochettino made a winning return to his former club.
Sitting 10th in the Premier League table, Chelsea will endeavour to head into the international break on a high and maintain their position in the top half by claiming a positive result against a Man City side, who have won each of their last five matches in all competitions.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of the contest with Pep Guardiola's side.
Enzo Fernandez
Status: Minor doubt
Type of injury: Knock
Possible return date: November 12 vs. Manchester City
Enzo Fernandez was on the receiving end of a strong challenge from Cristian Romero against Tottenham before coming off just before the hour mark with a knock, and the midfielder has emerged as a doubt for Sunday's match.
Armando Broja
Status: Minor doubt
Type of injury: Knee
Possible return date: November 12 vs. Manchester City
Armando Broja has been sidelined since the October international break due to a fresh knee problem, but the striker could be in a position to return to the matchday squad this weekend.
Wesley Fofana
Status: Out
Type of injury: Knee
Possible return date: Unknown
Wesley Fofana underwent knee surgery in the middle of July and the centre-back is facing a race against time to return before the 2023-24 season comes to a close.
Ben Chilwell
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Ben Chilwell has been sidelined since the end of September with a hamstring injury and the left-back is not expected to make a return until December at the earliest.
Christopher Nkunku
Status: Out
Type of injury: Knee
Possible return date: November 25 vs. Newcastle United
Christopher Nkunku is yet to make his competitive debut for Chelsea since joining the club in the summer due to a long-term knee injury, but the attacker could be in a position to return after the international break.
Romeo Lavia
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Romeo Lavia is another summer addition still waiting to make his Chelsea debut as he continues to recover from an ankle injury, and the teenage midfielder is not expected to return until December at the earliest.
Trevoh Chalobah
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Trevoh Chalobah is yet to feature for Chelsea this season due to a thigh injury and the versatile defender will once again miss out this weekend.
Carney Chukwuemeka
Status: Out
Type of injury: Knee
Possible return date: Unknown
Carney Chukwuemeka suffered a setback in his recovery from a knee injury last month and there is currently no timeframe on his potential return to first-team action.
Marcus Bettinelli
Status: Out
Type of injury: Unspecified
Possible return date: Unknown
Marcus Bettinelli has not made a matchday squad this season due to an unspecified injury, and it remains unclear when the goalkeeper could return to the first-team fold.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspended players for this match.