Thomas Tuchel's side were knocked out at the quarter-final stage by Real Madrid last season, having beaten Manchester City in the final in the previous campaign to lift the Champions League for the second time in their history.
The Blues came from behind to secure a much-needed 2-1 victory against West Ham United in the Premier League on Saturday afternoon, while Dinamo Zagreb extended their sizable lead at the top of their domestic division by beating Rijeka 3-1 on Friday.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of their contest with Dinamo Zagreb in Group E.
Pierre-Emerick Aubameyang
Status: Out
Type of injury: Jaw
Possible return date: September 18 (vs. Liverpool)
Pierre-Emerick Aubameyang's Chelsea debut will be delayed after the former Arsenal forward suffered a broken jaw while his previous house in Barcelona was robbed. Tuchel revealed Aubameyang will need to wear a protective mask before he can feature again, with a return to training not likely until next week.
N'Golo Kante
Status: Out
Type of injury: Hamstring
Possible return date: October 1 (vs. Crystal Palace)
N'Golo Kante was withdrawn in the closing stages of Chelsea's 2-2 draw against Tottenham Hotspur last month, with Tuchel revealing his key midfielder had picked up a hamstring injury. No specific time frame has been provided regarding Kante's return, but it is unlikely to be until after the September international break.
CHELSEA'S SUSPENSION LIST
Chelsea have no players suspended for the clash with Dinamo Zagreb.