The Blues booked their place in the final eight by beating Blackburn 2-0 while their opponents cruised to a 3-0 victory over Manchester United.
Eddie Howe's side got revenge on the Red Devils after they lost to Erik ten Hag's men in the final of this competition at Wembley last campaign.
However, as Toon continue to struggle with injuries, it will be Mauricio Pochettino who is out for revenge this time around.
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Live stream: Sky Sports Main Event / Sky Sports Football
Chelsea XI: Petrovic, Disasi, Silva, Badiashile, Colwill, Caicedo, Fernandez, Gallagher, Palmer, Sterling, Jackson.
Subs: Bettinelli, Bergstrom, Gilchrist, Gusto, Maatsen, Mudryk, Matos, Nkunku, Broja.
Newcastle XI: Dubravka, Krafth, Lascelles, Botman, Livramento, Guimaraes, Longstaff, Miley, Almiron, Gordon, Wilson.
Subs: Karius, Gillespie, Trippier, Dummett, Ritchie, Hall, Burn, Murphy.
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