Rigobert Song's side were condemned to a seventh consecutive group-stage defeat — a run dating back to the 2002 World Cup — as they were beaten 1-0 by Switzerland in Wednesday's group opener.
As for Serbia, they were simply outclassed by a star-studded Brazil side as Tottenham Hotspur forward Richarlison struck twice in the second half to hand the South Americans heavyweights a 2-0 victory.
Here Sports Mole looks at how the squads of Cameroon and Serbia weigh up against each other ahead of Monday's contest.
CAMEROON
Most valuable player:
Andre-Frank Zambo Anguissa (£32.7m)
Overall squad value:
£133.6m
Most capped player:
Vincent Aboubakar (92)
Leading goalscorer:
Vincent Aboubakar (33)
Total caps:
654
Total goals:
84
Oldest player:
Eric Maxim Choupo-Moting (33)
Youngest player:
Simon Ngapandouetnbu (19)
Average age:
26.3
SQUAD IN FULL
Goalkeepers: Andre Onana (Inter Milan), Devis Epassy (Abha), Simon Ngapandouetnbu (Marseille)
Defenders: Nicolas Nkoulou (Aris), Collins Fai (Al-Tai), Nouhou Tolo (Seattle Sounders), Jean-Charles Castelletto (Nantes), Olivier Mbaizo (Philadelphia Union), Enzo Ebosse (Udinese), Christopher Wooh (Rennes)
Midfielders: Andre-Frank Zambo Anguissa (Napoli), Pierre Kunde (Olympiacos), Samuel Gouet (Mechelen), Martin Hongla (Hellas Verona), Gael Ondoua (Hannover 96), Olivier Ntcham (Swansea City), Jerome Ngom (APEJES de Mfou)
Forwards: Vincent Aboubakar (Al-Nassr), Eric Choupo-Moting (Bayern Munich), Karl Toko Ekambi (Lyon), Christian Bassogog (Shanghai Shenhua), Moumi Ngamaleu (Dynamo Moscow), Jean-Pierre Nsame (Young Boys), Bryan Mbeumo (Brentford), Georges-Kevin Nkoudou (Besiktas), Souaibou Marou (Coton Sport)
SERBA
Most valuable player:
Dusan Vlahovic (£69.2m)
Overall squad value:
£310.9
Most capped player:
Dusan Tadic (92)
Leading goalscorer:
Aleksandar Mitrovic (50)
Total caps:
790
Total goals:
117
Oldest player:
Dusan Tadic (34)
Youngest player:
Strahinja Pavlovic (21)
Average age:
26.9
SQUAD IN FULL
Goalkeepers: Marko Dmitrovic (Sevilla), Predrag Rajkovic (Mallorca), Vanja Milinkovic-Savic (Torino)
Defenders: Stefan Mitrovic (Getafe), Nikola Milenkovic (Fiorentina), Strahinja Pavlovic (RB Salzburg), Milos Veljkovic (Werder Bremen), Filip Mladenovic (Legia Warsaw), Strahinja Erakovic (Crvena Zvezda), Srdjan Babic (Almeria)
Midfielders: Nemanja Gudelj (Sevilla), Sergej Milinkovic-Savic (Lazio), Sasa Lukic (Torino), Marko Grujic (Porto), Filip Kostic (Juventus), Uros Racic (Braga), Nemanja Maksimovic (Getafe), Ivan Ilic (Hellas Verona), Andrija Zivkovic (PAOK), Darko Lazovic (Hellas Verona)
Forwards: Dusan Tadic (Ajax), Aleksandar Mitrovic (Fulham), Dusan Vlahovic (Juventus), Filip Djuricic (Sampdoria), Luka Jovic (Fiorentina), Nemanja Radonjic (Torino)
Read more on Cameroon vs Serbia
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