In what was an uneventful 0-0 draw at Selhurst Park on Thursday night, the England international's second half dismissal has proved to be the biggest talking point.
Following VAR intervention, the 26-year-old was given a straight red card for a studs-up challenge on Nathaniel Clyne in the 76th minute.
Replays showed that there wasn't a great deal of contact, with the ex-Sheffield United striker's boot glancing off of the right-back's shin.
But referee Chris Kavanagh deemed the challenge as reckless, with Calvert-Lewin given his marching orders - much to the shock of former Arsenal and Chelsea star Lianne Sanderson.
Speaking on talkSPORT commentary, she said: "Absolute joke! Sorry, but I think that is a joke, I really do.
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"I don't think that is a red card at all, and none of the players out there think it is either!
"Look at them look at the reaction of the players, they don't even know what to do, it's a joke."
Sanderson added: "That's not a red card, and I feel for Dominic Calvert-Lewin, because he can't seem to buy any type of luck.
"That is just not a red card, some people will disagree. I don't actually think anybody here thinks it was a red card."
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Having his say, Sam Matterface stated: "I understand the flexing of the foot, the fact that the studs are showing, he's in danger of causing himself a problem with VAR.
"But I just don't think there was enough force."
Interjecting, Sanderson concluded: "It wasn't malicious. When you slow everything down, it always seems a lot worse."
Palace didn't make the most of their extra man, with the two teams barely threatening the opposing goalkeeper.
They will now play in a replay at Goodison Park for a place in the fourth round.