Fans had turned out at Turf Moor for what they hoped would be a promotion party, but Gareth Ainsworth's side had other ideas as they secured a much-needed 2-1 win to pull them away from the relegation zone.
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Sam Field gave QPR the lead midway through the second-half, before Manuel Benson levelled the match for the Clarets.
However, the Hoops wrapped up a surprise win when Chris Martin found the net just three minutes from time.
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While it'd be unfair to belittle QPR's victory, the result is something of a surprise given Burnley's statistical dominance.
The Clarets managed 21 shots on goal compared to QPR's six, while Vincent Kompany's side also boasted a staggering 81 per cent possession and a far superior passing accuracy of 89 per cent.
Already promoted, Burnley won't be too worried by failing to secure the Championship crown in this match, given that they need a maximum of three points more to win the title.
However, they might be worried by the ongoing speculation surrounding their manager.
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Kompany is one of the main names on the shortlist for the Chelsea job, a desirable role for a man who looks set for a managerial career at the highest level.
Whatever happens, the Manchester City legend will be taking his seat in a Premier League dugout come August, whether it's in Lancashire or in London, with Tottenham said to also be interested in the Belgian.