The Lilywhites head south on the back of a 2-1 Europa League win against Ferencvaros, while the Seagulls lost 4-2 to a Cole Palmer-inspired Chelsea last weekend, and here Sports Mole rounds up the team news for both clubs.
BRIGHTON & HOVE ALBION vs. TOTTENHAM HOTSPUR
BRIGHTON & HOVE ALBION
Out: Joao Pedro (ankle), Matt O'Riley (ankle), Jan Paul van Hecke (unspecified)
Doubtful: Simon Adingra (unspecified), Solly March (knee), James Milner (thigh), Brajan Gruda (unspecified), Joel Veltman (illness)
Sports Mole's predicted XI: Verbruggen; Veltman, Dunk, Igor, Estupinan; Enciso, Baleba, Hinshelwood; Rutter, Welbeck, Mitoma
TOTTENHAM HOTSPUR
Out: Wilson Odobert (hamstring), Richarlison (unspecified)
Doubtful: Son Heung-min (thigh), Destiny Udogie (thigh)
Sports Mole's predicted XI: Vicario; Porro, Romero, Van de Ven, Udogie; Kulusevski, Bentancur, Maddison; Johnson, Solanke, Werner
For data analysis of the most likely results, scorelines and more for this match please click here.