With the likes of Neymar, Vinicius Junior, Thiago Silva and Alisson adorning their roster, the Selecao head to the tournament heavily fancied to go all the way and lift the trophy.
Serbia, who are one of the dark horses heading to Qatar, enjoyed an unbeaten qualifying campaign, where they picked up six wins and two draws in Group A to finish three points above runners-up Portugal.
Here, Sports Mole looks at how the squads of Brazil and Serbia weigh up against each other ahead of Thursday's contest.
BRAZIL
Most valuable player:
Vinicius Junior (£103.7m)
Overall squad value:
£985.7
Most capped player:
Dani Alves (124)
Leading goalscorer:
Neymar (75)
Total caps:
952
Total goals:
161
Oldest player:
Dani Alves (39)
Youngest player:
Gabriel Martinelli (21)
Average age:
27.9
SQUAD IN FULL
Goalkeepers: Alisson Becker (Liverpool), Ederson (Manchester City), Weverton (Palmeiras)
Defenders: Dani Alves (UNAM Pumas), Danilo (Juventus), Alex Sandro (Juventus), Alex Telles (Sevilla), Bremer (Juventus), Eder Militao (Real Madrid), Marquinhos (Paris Saint-Germain), Thiago Silva (Chelsea)
Midfielders: Casemiro (Manchester United), Everton Ribeiro (Flamengo), Bruno Guimaraes (Newcastle United), Fabinho (Liverpool), Fred (Manchester United), Lucas Paqueta (West Ham United)
Forwards: Antony (Manchester United), Gabriel Jesus (Arsenal), Gabriel Martinelli (Arsenal), Neymar (Paris Saint-Germain), Pedro (Flamengo), Raphinha (Barcelona), Rodrygo (Real Madrid), Richarlison (Tottenham Hotspur), Vinicius Junior (Real Madrid)
SERBA
Most valuable player:
Dusan Vlahovic (£69.2m)
Overall squad value:
£310.9
Most capped player:
Dusan Tadic (91)
Leading goalscorer:
Aleksandar Mitrovic (50)
Total caps:
775
Total goals:
117
Oldest player:
Dusan Tadic (34)
Youngest player:
Strahinja Pavlovic (21)
Average age:
26.9
SQUAD IN FULL
Goalkeepers: Marko Dmitrovic (Sevilla), Predrag Rajkovic (Mallorca), Vanja Milinkovic-Savic (Torino)
Defenders: Stefan Mitrovic (Getafe), Nikola Milenkovic (Fiorentina), Strahinja Pavlovic (RB Salzburg), Milos Veljkovic (Werder Bremen), Filip Mladenovic (Legia Warsaw), Strahinja Erakovic (Crvena Zvezda), Srdjan Babic (Almeria)
Midfielders: Nemanja Gudelj (Sevilla), Sergej Milinkovic-Savic (Lazio), Sasa Lukic (Torino), Marko Grujic (Porto), Filip Kostic (Juventus), Uros Racic (Braga), Nemanja Maksimovic (Getafe), Ivan Ilic (Hellas Verona), Andrija Zivkovic (PAOK), Darko Lazovic (Hellas Verona)
Forwards: Dusan Tadic (Ajax), Aleksandar Mitrovic (Fulham), Dusan Vlahovic (Juventus), Filip Djuricic (Sampdoria), Luka Jovic (Fiorentina), Nemanja Radonjic (Torino)
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