Spurs' new state-of-the-art ground hosted two games in 2019 with the Oakland Raiders beating the Chicago Bears and the Carolina Panthers seeing off the Tampa Bay Buccaneers.
Now, London is ready to welcome two more matches in the 2021 season after last year's matches had to be cancelled due to the pandemic.
First up, it'll be Matt Ryan's 1&3 Falcons up against the Jets who have the same record so far this campaign.
The Falcons lost a 34-30 thriller to the Washington Football Team last weekend while the Jets got their season up and running by beating the Tennessee Titans.
The Jets have visited London once before, beating the Miami Dolphins 27-14 in 2015 while this will also be just the second time the Falcons have headed across the pond following their defeat to the Detroit Lions in 2014.
The Dolphins vs the Jacksonville Jaguars is coming up next weekend and talkSPORT will bring you both London games live.
Falcons vs Jets: talkSPORT commentary
The regular season clash will take place on Sunday, October 10 with kick-off at 1:20pm UK time.
You can also listen to the talkSPORT NFL Show broadcast every Sunday evening at 5pm with Nat Coombs, Will Gavin and special guests each week.
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Falcons vs Jets: What's been said?
Jets head coach Robert Saleh: "It's a tricky week. Fortunately I've been a part of this game three times.
"Once we tried leaving right after a Sunday game, then leaving on Monday, then on Thursday.
We have a really good travel plan to keep it as normal as possible for our guys, getting in, acclimated to the time change and playing on Sunday."