While the Bees overtook their second-city counterparts by winning again at the weekend, their absence list is a little longer than Villa's heading into the clubs' midweek contest.
Here, Sports Mole rounds up all the latest team news for both sides.
ASTON VILLA vs. BRENTFORD
ASTON VILLA
Out: Jacob Ramsey (hamstring)
Doubtful: Amadou Onana (ankle), Emiliano Martinez (hand)
Sports Mole's predicted XI: Olsen; Cash, Konsa, Torres, Maatsen; Barkley, Tielemans; Bailey, Rogers, McGinn; Watkins
BRENTFORD
Out: Josh Dasilva, Rico Henry (both knee), Aaron Hickey (thigh), Kristoffer Ajer (foot)
Doubtful: Gustavo Nunes (back), Mathias Jensen (hamstring)
Sports Mole's predicted XI: Flekken; Van den Berg, Collins, Pinnock, Lewis-Potter; Janelt, Norgaard; Mbeumo, Damsgaard, Schade; Wissa
For data analysis of the most likely results, scorelines and more for this match please click here. Written by
Jonathan O'Shea