And the north Londoners then face Bournemouth in Saturday's 3pm Premier League encounter, looking to get back to winning ways after Sunday's 2-2 draw against Tottenham.
Wingers Gabriel Martinelli and Leandro Trossard will play no part with the pair dealing with muscle injuries.
Meanwhile Declan Rice is unlikely to be involved against the Bees following his early exit in the north London derby due to a back problem.
Speaking in his press conference on Tuesday, Arteta than stated that forward Saka, who is Arsenal's top scorer this season with four goals, is another concern.
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Saka was withdrawn late on against Spurs, where he was spotted limping off the pitch.
Commenting on the 22-year-old, Arteta said: "He was limping quite badly after the match.
"We had to get him off the field which is never a good sign.
"He hasn't been able to participate in the session."
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Pressed on whether he may miss out on facing the Cherries this weekend, he conceded: "It's a possibility."
As for Ghanaian midfielder Thomas Partey, who has missed the last four games with a groin injury, Arteta insisted he remains unavailable for selection.
He remarked: "Still not available. It's a long list! Still not. The same with Jurrien [Timber].
"It's the situation that we have at moment that we have to adapt.
"The squad we have at the moment is really short and we need players back, that's for sure."