The Gunners have enjoyed an excellent Premier League campaign under Mikel Arteta but suffered a slip by falling to a 4-0 defeat at the hands of Liverpool last weekend.
For the Magpies it's quite simply a must-win clash with Eddie Howe's side without a victory in the Premier League this term.
Newcastle will need to get some points on the board and fast if they're to close the gap on top flight safety, however a clash with Arsenal is far from the ideal encounter to do that.
Arsenal v Newcastle United: talkSPORT commentary
The Premier League clash is due to take place on Saturday, November 27 at the Emirates Stadium in London.
Kick-off is set for 12.30pm UK time.
talkSPORT will have exclusive coverage of the clash with Reshmin Chowdhury presenting while commentary comes from Sam Matterface and former England striker Dean Ashton.
To tune in to talkSPORT or talkSPORT 2, click HERE for the live stream.
App iPhone - Download from the Apple store
Android - Download from Google Play
Radio - talkSPORT is available across the United Kingdom via DAB digital radio and on 1089 or 1053 AM
TV - Listen to talkSPORT through your TV on the following channels: Sky: Channel 0108 Virgin Media: Channel 927 Freeview: Channel 723 Freesat: Channel 731
Arsenal v Newcastle United: Team news
Arteta has a near-full strength side to choose from ahead of the weekend clash with the Magpies.
Arsenal's only absentees are Granit Xhaka and Sead Kolasinac who are long-term absentees.
Newcastle will also have almost a fully fit squad to choose from with Paul Dummett the only the player likely to miss out.
Arsenal v Newcastle United: What's been said?
Mikel Arteta: "We are really looking forward to the game, as I said after a defeat you want to put it right straight away.
"In a different context, we are on a good run, we play at home, we are going to have our people right behind us and we are going to perform well.
First of all, play as well as we can and we will be closer to winning the match."
Arsenal v Newcastle United: Match facts
Arsenal have won 16 of their last 17 Premier League games against Newcastle, with the exception being a 2-1 away loss in April 2018.
Since a 1-0 victory in November 2010, Newcastle have lost each of their last nine away league games against Arsenal, failing to score in each of the last five.
Arsenal have scored at least once in each of their last 17 Premier League games against Newcastle. The Gunners have opened the scoring in their last 16 against Newcastle, the longest run one team has had scoring first against another in the competition's history.
Arsenal have never lost a Premier League home game against the side starting the day bottom of the table (W15 D6), winning the last eight in a row by an aggregate score of 23-2.
Arsenal lost at Liverpool last time out, ending their eight-game unbeaten run in the Premier League (W6 D2). Indeed, the Gunners conceded as many goals in their 4-0 loss at Anfield as they had in their eight-game run combined.
Newcastle are the only side still without a win in the top four tiers of English league football this season (D6 L6). Their current run of 12 Premier League games without a win is their longest since a run of 13 between December 2007 and March 2008.
No side have conceded more Premier League goals than Newcastle this season (27), with the Magpies still yet to keep a clean sheet this term. However, they've scored more goals (15) than opponents Arsenal (13) so far this term.
Pierre-Emerick Aubameyang has been involved in nine goals in his eight appearances for Arsenal against Newcastle in all competitions (6 goals, 3 assists), scoring in each of his last five against the Magpies.
Newcastle manager Eddie Howe has taken just five points from 30 available in his Premier League meetings with Arsenal (W1 D2 L7), losing all five of his visits to the Emirates to face the Gunners.
Newcastle's Allan Saint-Maximin has carried the ball further than any other player in the Premier League this season (2952 metres), while no player has created more chances following a ball carry than the Frenchman (13, level with Jack Grealish).